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It is normal for Romazine
100 to cause cardiopulmonary depression manifested by a decrease in heart rate,
stroke volume, cardiac output and respiratory rate together with an increase in
total peripheral resistance. These effects are transitory and of no clinical
significance in healthy horses. However, it is not recommended to use
Xylazil-100 where there is cardiovascular disease including conditions of shock
or respiratory depression.
A number of cardiac dysrhythmias such as second degree atrioventricular blocks have been encountered
with xylazine administration and it is believed that increased vagal tone is
responsible for these. Premedication with atropine sulphate will help prevent
their occurrence although care must be taken, as atropine sulphate is known to
be associated with colic in the Horse.
Romazine 100 should not be
administered to mares in the last trimester of pregnancy as it may precipitate
an early parturition of abortion due to its oxytocic effect on the uterus.
Romazine 100 should not be
administered intra-arterially.
Painful stimuli may cause an
apparently deeply sedated patient to react inappropriately and therefore
adequate care should be taken.
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