Creatine is an essential natural substance required for energy during a brief period of high intensity exercise. The ATP demand in the working muscles increase significantly to several-hundred times higher versus when at rest. The ATP in body is stored little, and it must be composed continuously. However, the slow speed of composement effects the sports ability and cause tiredness. Therefore, the supplement of creatine can effectively improve the strength , speed and endurance of muscles, then it can enhance the level of athletic  performance and resist fatigue .

Synthesis, Distribution, excretion and function

[NH₂-C(NH)-NCH₂(COOH)-CH₃], is a naturally occurring compound that helps to supply energy to the muscle cells. Typically, half of the creatine (Cr) in our body comes from the food we eat (mainly from meat and fish), while the other half is synthesized from certain amino acids.

Derived from the amino acids arginine, glycine and methionine, creatine is made by your body primarily in the liver, pancreas and kidneys. Creatine can be transported into the muscle via the bloodstream. Under the affection of phosphatecreatine enzymes, it produces phosphatecreatine and is evacuated by kidney.

Creatine plays a powerful role in the muscle and cell because Adenosine Triphosphate (ATP) is always ready to supply energy to the muscles. And all nutrients such as carbohydrates, fats and protein are provided to the body’s energy via ATP. Then ATP releases a phosphate molecule, which creates energy and turns ATP into Adenosine Diphosphate (ADP). Creatine phosphate gives up its phosphate molecule to ADP which changes it back into ATP. The cycle starts over again until creatine phosphate supply is diminished. The producing energy maintains the muscle shrink and cell activity, and the free form of creatine are stored in muscles and can be changed into phosphatecreatine again.

So the energy source of muscle shrink and cell activity is creatine or phosphatecreatine.

The supplement of creatine loses balance on the high intensity exercises under over-fatigue and sickness condition because the creatine of your body is obtained from a diet rich in meat or fish and made by body. So it needs additional supplement.

Creatine has great function to all kinds of neuro-muscle illness as nutriment for special groups of people.

The amyotrophia and side-collarbone sclerosis experiment of G93A on gene-change little rats carried out. The experiment proved that creatine could protect the motor neuron from dying and increase the living time. Therefore it’s good for the therapy of amyotrophia and side-collarbone sclerosis, especially for improving the function of swallowing and speaking.

The experiment of brain trauma of animals proved that creatine could help the brain recover from traumatic head injuries.

The experiment proved that creatine could protect special kinds of brain neuron from injuring. The creatine is useful for the patient of parkinsonism.

The research of neuromuscular such as musclecacotrophia, innate muscle illness, muscle inflammation, Chondriosome illness, brain muscle illness and other neuromuscular illness proved that creatine can improve muscle force, and help patients with neuromuscular disease recover.

It is also useful for the illness of muscular fatigue, such as the illness of fat buildup and fatigue syndrome.